abstract：:Three vanadium complexes of chlorodipicolinic acid (4-chloro-2,6-dipicolinic acid) in oxidation states III, IV, and V were prepared and their properties characterized across the oxidation states. In addition, the series of hydroxylamido, methylhydroxylamido, dimethylhydroxylamido, and diethylhydroxylamido complexes we...

journal_title：Journal of inorganic biochemistry

authors： Smee JJ,Epps JA,Ooms K,Bolte SE,Polenova T,Baruah B,Yang L,Ding W,Li M,Willsky GR,la Cour A,Anderson OP,Crans DC

更新日期：2009-04-01 00:00:00

abstract：:In this brief review the most recent studies and the most relevant aspects of the complexes generated by interaction of carbohydrates and related molecules with the oxovanadium(IV) cation, VO(2+), are presented and discussed. The survey includes complexes of mono-, di- and polysaccharides, and of other molecules relat...

journal_title：Journal of inorganic biochemistry

authors： Baran EJ

更新日期：2009-04-01 00:00:00

abstract：:A previous evaluation of the insulin-like activity of three 3-hydroxy-4-pyridinonato oxidovanadium(IV) complexes raised questions about structure/activity relationships, namely the influence of the hydrophilic/lipophilic balance of the complex and the capacity of the ligand to stabilize the +4 oxidation state of vanad...

journal_title：Journal of inorganic biochemistry

authors： Rangel M,Amorim MJ,Nunes A,Leite A,Pereira E,de Castro B,Sousa C,Yoshikawa Y,Sakurai H

更新日期：2009-04-01 00:00:00

abstract：:To characterize heme oxygenase with a selenocysteine (SeCys) as the proximal iron ligand, we have expressed truncated human heme oxygenase-1 (hHO-1) His25Cys, in which Cys-25 is the only cysteine, in the Escherichia coli cysteine auxotroph strain BL21(DE3)cys. Selenocysteine incorporation into the protein was demonstr...

journal_title：Journal of inorganic biochemistry

authors： Jiang Y,Trnka MJ,Medzihradszky KF,Ouellet H,Wang Y,Ortiz de Montellano PR

更新日期：2009-03-01 00:00:00

abstract：:Metallothioneins are small cysteine-rich proteins believed to play a role, among others, in the homeostasis of essential metal ions such as Zn(II) and Cu(I). Recently, we could show that wheat E(c)-1 is coordinating its six Zn(II) ions in form of metal-thiolate clusters analogously to the vertebrate metallothioneins. ...

journal_title：Journal of inorganic biochemistry

authors： Peroza EA,Kaabi AA,Meyer-Klaucke W,Wellenreuther G,Freisinger E

更新日期：2009-03-01 00:00:00

abstract：:MicroRNAs (miRNAs) are a novel class of short, endogenous non-coding small RNAs that have the ability to base pair with their target mRNAs to repress their translation or induce their degradation in both plants and animals. To identify heavy metal stress-regulated novel miRNAs, we constructed a library of small RNAs f...

journal_title：Journal of inorganic biochemistry

authors： Huang SQ,Peng J,Qiu CX,Yang ZM

更新日期：2009-02-01 00:00:00

abstract：:We have surveyed the chemical utility of the near-edge structure of molybdenum X-ray absorption edges from the hard X-ray K-edge at 20,000eV down to the soft X-ray M(4,5)-edges at approximately 230eV. We compared, for each edge, the spectra of two tetrahedral anions, MoO(4)(2-) and MoS(4)(2-). We used three criteria f...

journal_title：Journal of inorganic biochemistry

authors： George SJ,Drury OB,Fu J,Friedrich S,Doonan CJ,George GN,White JM,Young CG,Cramer SP

更新日期：2009-02-01 00:00:00

abstract：:The glyoxalase system catalyzes the conversion of toxic methylglyoxal to nontoxic d-lactic acid using glutathione (GSH) as a coenzyme. Glyoxalase II (GlxII) is a binuclear Zn enzyme that catalyzes the second step of this conversion, namely the hydrolysis of S-d-lactoylglutathione, which is the product of the Glyoxalas...

journal_title：Journal of inorganic biochemistry

authors： Chen SL,Fang WH,Himo F

更新日期：2009-02-01 00:00:00

abstract：:The title compound ([3,5-Me(2)bpzaH(2)][AuCl(4)]Cl, 1) (Me(2)bpza=bis(3,5-dimethylpyrazolyl)acetic acid), was prepared by reacting H[AuCl(4)] with 3,5-Me(2)bpza; and spectroscopically and structurally characterized. In the solid state structure of 1, the pyrazolyl ligand is doubly protonated to form two strong charge ...

journal_title：Journal of inorganic biochemistry

authors： Fonteh PN,Keter FK,Meyer D,Guzei IA,Darkwa J

更新日期：2009-02-01 00:00:00

abstract：:Calcium functions as a secondary messenger within the cytosols of eukaryotes. This serves as a reference point to evaluate three related questions:Exploration of these three interrelated questions indicates the importance of more sensitive techniques and of a refined concept of information transfer and transduction. 1...

journal_title：Journal of inorganic biochemistry

authors： Permyakov EA,Kretsinger RH

更新日期：2009-01-01 00:00:00

abstract：:In this work we present results of density functional theory (DFT) calculations on dicopper patellamides and their affinity for molecular oxygen and carbonate. Patellamides are cyclic octapeptides that are produced by a cyanobacterium, and may show promise as therapeutics. Thus, carbonate binding to a dicopper patella...

journal_title：Journal of inorganic biochemistry

authors： Latifi R,Bagherzadeh M,Milne BF,Jaspars M,de Visser SP

更新日期：2008-12-01 00:00:00

abstract：:The reaction of 3-methoxyphenylacetic acid (3-MPAH), 4-methoxyphenylacetic acid (4-MPAH), 2,5-dimethyl-3-furoic acid (DMFUH) or 1,4-benzodioxane-6-carboxylic acid (BZDOH) with triphenyltin(IV) chloride (1:1) or diphenyltin(IV) dichloride (2:1) in the presence of triethylamine yielded the compounds [SnPh3(3-MPA)] (1), ...

journal_title：Journal of inorganic biochemistry

authors： Gómez-Ruiz S,Kaluderović GN,Prashar S,Hey-Hawkins E,Erić A,Zizak Z,Juranić ZD

更新日期：2008-12-01 00:00:00

abstract：:Metals such as CuI and FeII generate hydroxyl radical (.OH) by reducing endogenous hydrogen peroxide (H2O2). Because antioxidants can ameliorate metal-mediated oxidative damage, we have quantified the ability of glutathione, a primary intracellular antioxidant, and other biological sulfur-containing compounds to inhib...

journal_title：Journal of inorganic biochemistry

authors： Battin EE,Brumaghim JL

更新日期：2008-12-01 00:00:00

abstract：:Human metallothionein-3 (hMT3), also named as human neuronal growth inhibitory factor (hGIF), can inhibit the outgrowth of embryonic cortical neurons in the presence of brain extracts. In order to systematically study the structure-property-reactivity-function relationship of hGIF, our laboratory designed a series of ...

journal_title：Journal of inorganic biochemistry

authors： Ding ZC,Zheng Q,Cai B,Ni FY,Yu WH,Teng XC,Gao Y,Liu F,Chen D,Wang Y,Wu HM,Sun HZ,Zhang MJ,Tan XS,Huang ZX

更新日期：2008-11-01 00:00:00

abstract：:A new ligand, N,N'-dibenzylethane-1,2-diamine (L) and its four transition metal(II) complexes, ML(2)(OAc)(2).2H(2)O (M=Cu, Ni, Zn, Co), have been synthesized and characterized by elemental analysis, mass spectra, molar conductivity, NMR and IR. Moreover, the crystals structure of Cu(II) and Ni(II) complexes characteri...

journal_title：Journal of inorganic biochemistry

authors： Wu SS,Yuan WB,Wang HY,Zhang Q,Liu M,Yu KB

更新日期：2008-11-01 00:00:00

abstract：:Interaction of Delta,Delta- and Lambda,Lambda-bis-Ru(II) complexes with native DNA was investigated by isotropic absorption and polarized spectroscopy including circular and linear dichroism (CD and LD). Despite the steric hindrance originating from its four bulky phenanthroline ligands at both ends of the molecule, t...

journal_title：Journal of inorganic biochemistry

authors： Jang YJ,Kwon BH,Choi BH,Bae CH,Seo MS,Nam W,Kim SK

更新日期：2008-10-01 00:00:00

abstract：:The cysteine proteases of the trypanosomatid parasitic protozoa have been validated as targets for chemotherapy of Chagas' disease and leishmaniasis. Metal complexes of gold, platinum, iridium, palladium, rhodium and osmium have been reported to have activity against a variety of trypanosomatids, but the molecular tar...

journal_title：Journal of inorganic biochemistry

authors： Fricker SP,Mosi RM,Cameron BR,Baird I,Zhu Y,Anastassov V,Cox J,Doyle PS,Hansell E,Lau G,Langille J,Olsen M,Qin L,Skerlj R,Wong RS,Santucci Z,McKerrow JH

更新日期：2008-10-01 00:00:00

abstract：:We present the facile technique of colorimetric SNP (single nucleotide polymorphism) analysis through DNA-templated cooperative complexation between a luminescent lanthanide ion (Ln(III): Tb(III) or Eu(III)) and two ODN (oligodeoxyribonucleotide) conjugates carrying a metal chelator. Families of complexane-type chelat...

journal_title：Journal of inorganic biochemistry

authors： Kitamura Y,Ihara T,Tsujimura Y,Osawa Y,Sasahara D,Yamamoto M,Okada K,Tazaki M,Jyo A

更新日期：2008-10-01 00:00:00

abstract：:Vanadate has been recognized as a specific and potent phosphatase inhibitor since its structure is similar to that of phosphate. In this study, we measured the inhibition of glutathione S-transferase-tagged protein tyrosine phosphatase 1B (GST-PTP1B) and alkaline phosphatase (ALP) by the insulin enhancing compounds, b...

journal_title：Journal of inorganic biochemistry

authors： Li M,Ding W,Baruah B,Crans DC,Wang R

更新日期：2008-10-01 00:00:00

abstract：:A series of cis-bis{5-[(E)-2-(aryl)-1-diazenyl]quinolinolato}di-n-butyltin(IV) complexes has been synthesized and characterized by (1)H-, (13)C-, (119)Sn NMR, ESI-MS (electrospray ionization mass spectrometry), IR and (119m)Sn Mössbauer spectroscopic techniques in combination with elemental analyses. The structures of...

journal_title：Journal of inorganic biochemistry

authors： Basu Baul TS,Mizar A,Chandra AK,Song X,Eng G,Jirásko R,Holcapek M,de Vos D,Linden A

更新日期：2008-09-01 00:00:00

abstract：:Four related ruthenium(III) complexes, with the formula mer-[RuCl(3)(dmso)(N-N)] (dmso=dimethyl sulfoxide; N-N=2,2'-bipyridine (1), 1,10-phenantroline (2), dipyrido[3,2-f:2',3'-h]quinoxaline (3) and dipyrido[3,2-a:2',3'-c]phenazine (4)), have been reported. Complexes 3 and 4 are newly synthesized and characterized by ...

journal_title：Journal of inorganic biochemistry

authors： Tan C,Liu J,Chen L,Shi S,Ji L

更新日期：2008-08-01 00:00:00

abstract：:We present a comprehensive analysis of the most likely ground state configuration of the resting state of vanadium dependent chloroperoxidase (VCPO) based on quantum mechanics/molecular mechanics (QM/MM) evaluations of ground state properties, UV-vis spectra and NMR chemical shifts. Within the QM/MM framework, density...

journal_title：Journal of inorganic biochemistry

authors： Zhang Y,Gascón JA

更新日期：2008-08-01 00:00:00

abstract：:Chromium(VI) compounds (e.g. chromates) are cytotoxic, mutagenic, and potentially carcinogenic. The reduction of Cr(VI) can yield reactive intermediates such as Cr(V) and reactive oxygen species. Bronchial epithelial cells are the primary site of pulmonary exposure to inhaled Cr(VI) and are the primary cells from whic...

journal_title：Journal of inorganic biochemistry

authors： Borthiry GR,Antholine WE,Myers JM,Myers CR

更新日期：2008-07-01 00:00:00

abstract：:Coordination properties toward Fe(III) and Al(III) of a mixed bisphosphonate-hydroxypyridinonate ligand are presented. Potentiometric, spectrophotometric and NMR results allowed to conclude that Fe(III) and Al(III) coordination takes place on the pyridinone moiety. The high steric hindrance prevents the possibility of...

journal_title：Journal of inorganic biochemistry

authors： Crisponi G,Nurchi VM,Pivetta T,Gałezowska J,Gumienna-Kontecka E,Bailly T,Burgada R,Kozłowski H

更新日期：2008-07-01 00:00:00

abstract：:There is considerable interest today for the reactions of anticancer metallodrugs with proteins as these interactions might feature processes that are crucial for the biodistribution, the toxicity and even the mechanism of action of this important group of anticancer agents. We survey here the results of research acti...

journal_title：Journal of inorganic biochemistry

authors： Casini A,Guerri A,Gabbiani C,Messori L

更新日期：2008-05-01 00:00:00

abstract：:The reaction between [(eta(6)-p-cymene)Ru(H2O)3]X2 and 4,7-phenanthroline (phen) leads to the formation of the rectangular tetranuclear complexes [(eta(6)-p-cymene)4Ru4(mu-4,7-phen-N4,N7)(2)(mu-OH)4]X4 (X=NO3, 1a; SO3CF3, 1b) which have been structurally characterised by X-ray crystallography. 1H NMR spectroscopic stu...

journal_title：Journal of inorganic biochemistry

authors： Galindo MA,Quirós M,Romero MA,Navarro JA

更新日期：2008-05-01 00:00:00

abstract：:The effects of the divalent alkaline-earth metal ions (Ca2+ and Mg2+) on the substrate binding affinity, spin-state transition at the heme active site, conformational properties as well as the stability of the active form of cytochrome P450cam (CYP 101) have been investigated using various spectroscopic and kinetic me...

journal_title：Journal of inorganic biochemistry

authors： Manna SK,Mazumdar S

更新日期：2008-05-01 00:00:00

abstract：:The chemical structures of the pentavalent antimonial drugs, meglumine antimonate (MA) and sodium stibogluconate (SSG), were re-evaluated using electrospray ionization mass spectrometry (ESI-MS) and osmolarity measurements. Both MA and SSG were found to contain 1:1, 1:2, 2:2 and 2:3 Sb(V)-ligand complexes. ESI-MS anal...

journal_title：Journal of inorganic biochemistry

authors： Frézard F,Martins PS,Barbosa MC,Pimenta AM,Ferreira WA,de Melo JE,Mangrum JB,Demicheli C

更新日期：2008-04-01 00:00:00

abstract：:Cellular uptake of a drug is one of the most important factors influencing its pharmacodynamics and pharmacokinetics. Our laboratory has previously studied platinum uptake following cisplatin, carboplatin and oxaliplatin treatment at sub-lethal doses of selected tumour cell lines. Here we report on the influence of te...

journal_title：Journal of inorganic biochemistry

authors： Gabano E,Colangelo D,Ghezzi AR,Osella D

更新日期：2008-04-01 00:00:00

abstract：:Recent findings on the photophysical investigations of several cofacial bisporphyrin dyads for through space singlet and triplet energy transfers raised several serious questions about the mechanism of the energy transfers and energy migration in the light harvesting devices, notably LH II, in the heavily studied purp...

journal_title：Journal of inorganic biochemistry

authors： Harvey PD,Stern C,Gros CP,Guilard R

更新日期：2008-03-01 00:00:00

abstract：:Three of the most plausible biological theories of arsenic carcinogenesis are protein binding, oxidative stress and altered DNA methylation. This review presents the role of trivalent arsenicals binding to proteins in arsenic carcinogenesis. Using vacuum filtration based receptor dissociation binding techniques, the l...

journal_title：Journal of inorganic biochemistry

authors： Kitchin KT,Wallace K

更新日期：2008-03-01 00:00:00

abstract：:A combination of magnetic circular dichroism (MCD), electronic absorption spectroscopy and time-dependent density functional theory (TD-DFT) calculations has been used to investigate the electronic structure of azulene-fused pi-expanded porphyrins based primarily on the spectral properties of absorption bands in the n...

journal_title：Journal of inorganic biochemistry

authors： Nakai K,Kurotobi K,Osuka A,Uchiyama M,Kobayashi N

更新日期：2008-03-01 00:00:00

abstract：:M98Q amicyanin is isolated with zinc bound to its type 1 copper-binding site. The influence of the axial ligand of the type 1 copper site on metal specificity is strongest prior to the completion of protein folding and adoption of the final type 1 site geometry. The preference for zinc over copper correlated with the ...

journal_title：Journal of inorganic biochemistry

authors： Ma JK,Lee S,Choi M,Bishop GR,Hosler JP,Davidson VL

更新日期：2008-02-01 00:00:00

abstract：:The synthesis, structural characterization, voltammetric experiments and antibacterial activity of [Ni(sulfisoxazole)(2)(H(2)O)(4)].2H(2)O and [Ni(sulfapyridine)(2)] were studied and compared with similar previously reported copper complexes. [Ni(sulfisoxazole)(2)(H(2)O)(4)].2H(2)O crystallized in a monoclinic system,...

journal_title：Journal of inorganic biochemistry

authors： Mondelli M,Bruné V,Borthagaray G,Ellena J,Nascimento OR,Leite CQ,Batista AA,Torre MH

更新日期：2008-02-01 00:00:00

abstract：:An iron porphycene, a structural isomer of iron porphyrin, with trifluoromethyl groups at the peripheral position of the framework was incorporated into sperm whale apomyoglobin. The prepared myoglobin shows the higher O(2) affinity than the native protein. However, the oxygen affinity of the reconstituted myoglobin i...

journal_title：Journal of inorganic biochemistry

authors： Matsuo T,Ito K,Nakashima Y,Hisaeda Y,Hayashi T

更新日期：2008-02-01 00:00:00

abstract：:The amyloidogenic peptide amylin is found associated with pancreatic islet beta-cells and is implicated in the aetiology of type-2 diabetes mellitus. We have used fluorimetry and transmission electron microscopy to investigate in vitro the influence of Al(III), Fe(III), Zn(II) and Cu(II) on amylin amyloid formation un...

journal_title：Journal of inorganic biochemistry

authors： Ward B,Walker K,Exley C

更新日期：2008-02-01 00:00:00

abstract：:The copper(II)-5-fluorosalicylic acid system was investigated in water and 50 v/v% water-methanol mixture by pH potentiometry combined with UV-vis spectrophotometry, and by the two-dimensional ESR simulation method, respectively. The data revealed that the stable paramagnetic mono- and bis(salicylato) copper(II) compl...

journal_title：Journal of inorganic biochemistry

authors： Szabó-Plánka T,Gyurcsik B,Nagy NV,Rockenbauer A,Sípos R,Sima J,Melník M

更新日期：2008-01-01 00:00:00

abstract：:The action mechanism of vanadocene dichloride, Cp2VCl2 (Cp=eta5-C5H5), has been investigated by interaction with human serum transferrin for its promising antitumor activities. Our results have shown that Cp2VCl2 binds to transferrin and form a new complex, and the calculated apparent association constant is 1.37 x 10...

journal_title：Journal of inorganic biochemistry

authors： Du H,Xiang J,Zhang Y,Tang Y,Xu G

更新日期：2008-01-01 00:00:00

abstract：:The interaction of heme or heme-artemisinin adducts (heme-art) with different peptides mimicking repeat sequences of the Histidine-Rich-Protein-II of Plasmodium falciparum (PfHRP-II) was investigated. The pseudo-first order rate constants of the coordination of heme or heme-art onto a histidine rich peptide, used as a...

journal_title：Journal of inorganic biochemistry

authors： Accardo A,Laurent SA,Mazarguil H,Meyer M,Robert A,Meunier B

更新日期：2007-11-01 00:00:00

abstract：:The interaction of nitric oxide (NO) with iron-sulfur cluster proteins results in the formation of dinitrosyl iron complexes (DNICs) coordinated by cysteine residues from the peptide backbone or with low molecular weight sulfur-containing molecules like glutathione. Such DNICs are among the modes available in biology ...

journal_title：Journal of inorganic biochemistry

authors： Harrop TC,Song D,Lippard SJ

更新日期：2007-11-01 00:00:00